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Summit Therapeutics

NASDAQ: SMMT $14.32 USD~$15B MCAP

Summit Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of innovative therapies for serious unmet medical needs, with a leading oncology asset ivonescimab (a PD-1/VEGF bispecific antibody) in-licensed from Akeso for global development.

Company Info

Sector:Biopharmaceuticals / Oncology
Headquarters:Miami, Florida, USA (research operations in Cambridge, UK)
Founded:2003

Upcoming Milestones & Key Dates

Q3 2026
Regulatory

FDA decision on ivonescimab BLA for 1L NSCLC

Q4 2026
Clinical Trial

HARMONi-3 confirmatory trial interim readout

Clinical Development Pipeline

Ivonescimab (AK112/SMT112)

Target: PD-1/VEGF bispecific antibody
First-line metastatic non-squamous NSCLC (HARMONi-2, HARMONi trials)
Preclinical
Phase 1
Phase 2
Phase 3
Approved

Ivonescimab

Target: PD-1/VEGF bispecific antibody
Other solid tumors (HCC, TNBC, gastric cancer) — multiple expansion cohorts
Preclinical
Phase 1
Phase 2
Phase 3
Approved

SMT-001

Target: Disclosed in 2026 R&D update
Investigational oncology bispecific
Preclinical
Phase 1
Phase 2
Phase 3
Approved

Recent News

Business & StrategyEndpoints News

Summit Withdraws $500M Offering, Citing 'Market Conditions'

Summit Therapeutics pulled a planned $500M follow-on offering, citing unfavorable market conditions just weeks after presenting mixed Phase 3 ivonescimab data that triggered a sharp selloff in its shares.

Leadership Team

Robert W. Duggan

Chairman and Chief Executive Officer

Maky Zanganeh

Vice-Chair, President and Chief Operating Officer

Dr. Allen Yang

Chief Medical Officer

Careers & Job Openings

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Multiple Departments
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