Neumora, enGene cut staff in cost-saving initiatives
Neuroscience biotech Neumora and genetic medicines company enGene both announce workforce reductions as part of cost-saving initiatives amid a broader sector pullback.
Neumora Therapeutics
Neumora Therapeutics is a clinical-stage neuroscience company developing precision medicines for brain diseases with high unmet need. Its lead asset NMRA-140 (navacaprant) is a kappa opioid receptor antagonist studied in major depressive disorder, and the company has additional programs in schizophrenia and other CNS indications. Following two Phase 3 failures in mid-2026, Neumora announced a 35% workforce reduction and is discontinuing development of its lead depression asset.
Company Info
Sector: Biotechnology / Neuroscience (Precision Psychiatry)
Headquarters: Watertown, Massachusetts, USA
Founded: 2019
Website: neumoratx.com/
Upcoming Milestones & Key Dates
Q3 2026
Corporate
Completion of 35% workforce reduction and pipeline restructuring
Late 2026
Corporate
Strategic review of remaining pipeline and cash runway guidance
Clinical Development Pipeline
NMRA-140 (navacaprant)
Target: Kappa opioid receptor (KOR) antagonistNMRA-140 (navacaprant)
Target: Kappa opioid receptor (KOR) antagonistPreclinical KOR / DOR programs
Target: Opioid receptor modulatorsRecent News
Neumora Discards Depression Asset, Lays Off Staffers After Pair of Late-Stage Flops
Neumora Therapeutics is laying off 35% of its workforce and discontinuing its lead depression drug after the asset failed two Phase 3 trials, sending shares down sharply and forcing a major pipeline reset.
Neumora Drug Fails Two More Phase 3 Trials, Biotech to Lay Off 35% of Staff
Endpoints News exclusive: Neumora Therapeutics is cutting 35% of staff and shelving its lead depression drug after two more Phase 3 trials missed, the latest in a wave of high-profile central nervous system setbacks.
Leadership Team
Henry Gosebruch
President and Chief Executive Officer
To be confirmed
Chief Medical Officer
To be confirmed
Chief Scientific Officer
Careers & Job Openings