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Madrigal Pharmaceuticals

NASDAQ: MDGL $505.75 USD ~$7.5B MCAP

Madrigal Pharmaceuticals is a clinical-stage biopharmaceutical company that developed and commercialized Rezdiffra (resmetirom), the first FDA-approved treatment for MASH (metabolic dysfunction-associated steatohepatitis) with moderate-to-severe liver fibrosis. The company is now pursuing expanded indications and next-generation oral small-molecule therapeutics for liver and metabolic diseases.

Company Info

Sector: Biotechnology / Metabolic Disease
Headquarters: West Conshohocken, Pennsylvania, USA
Founded: 2011

Upcoming Milestones & Key Dates

Q2 2026
Earnings

Q1 2026 Earnings Conference Call and Rezdiffra launch trajectory update

Late 2026 / 2027
Clinical Trial

MAESTRO-NASH OUTCOMES Phase 3 readout (cirrhosis F4)

October 2026
Conference

The Liver Meeting (AASLD) — MASH clinical data presentations

Clinical Development Pipeline

Rezdiffra (resmetirom)

Target: Thyroid hormone receptor beta (THR-β) selective agonist
MASH with moderate-to-severe liver fibrosis (F2-F3)
Preclinical
Phase 1
Phase 2
Phase 3
Approved

Rezdiffra (resmetirom)

Target: THR-β selective agonist
Compensated MASH cirrhosis (F4) — MAESTRO-NASH OUTCOMES trial
Preclinical
Phase 1
Phase 2
Phase 3
Approved

Ervogastat

Target: DGAT-2 inhibitor
Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Preclinical
Phase 1
Phase 2
Phase 3
Approved

Recent News

Leadership Team

Bill Sibold

President and Chief Executive Officer

Mardi C. Dier

Executive Vice President, Chief Financial Officer

Dr. David Soergel, M.D.

Senior Vice President, Head of Clinical Development

Careers & Job Openings

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Multiple Departments
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